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Spyre Therapeutics Inc. (SYRE) — chart, structure and Closelooknet read

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Signals for this name

Every Closelooknet reading that exists for SYRE, from the same nightly bakes the boards use. Research diary readings, not advice.

Weather around the name 4 macro readings: Money Temperature, Factor regime, Sector × region …

The weather around this name

Macro readings that apply by membership — the regime, the factor tape, the sector cell, the funding backdrop.

  • Money Temperature Composite 61/100 · S&P 500 fund at 75, bullish alignedEight instruments scored on position, momentum, volume, volatility and fragility — the regime every name trades inside. Temperature lab → 2026-10-06
  • Factor regime Momentum leading — risk appetite buildingMomentum against low volatility (SPMO / SPLV): above its 50-day trend, 98th percentile of the window, +5.7% over 20 sessions. Factor regime → 2026-10-06
  • Sector × region Health care in US: −2.1% week · −2.2% month · +3.3% quarter · +16.4% yearThe Sector Engine cell this name lives in, from XLV.US; the 11 × 4 matrix shows where its sector is being bought and where it is being sold. Sector Engine → 2026-10-06
  • Sovereign pressure Index 0.74 · up 0.17 over 21 sessionsG7 long-end yields, 10s30s and the slope — the funding weather for every balance sheet on this site. Sovereign pressure → 2026-10-06
How it trades on rate days beta 0.79 to TLT · on the worst bond days it fell more than the market

How it trades on rate days

How SYRE has moved when long-dated Treasury yields rise — measured against TLT, the 20+ year Treasury fund.

  • Beta to long bonds, 1 year 0.79 — shows only a loose link to bond moves for every 1% move in TLT (20+ year Treasuries), Spyre Therapeutics Inc. moved 0.79% on average · correlation 0.11 · higher than 77% of US names
  • Beta, last 3 months 1.32 more rate-sensitive lately than over the year
  • On the 10 worst bond days −1.36% on average against −0.74% for the S&P 500 the 10 sessions of the past year in which TLT fell most, i.e. long yields rose most
  • Latest of those days −1.22% TLT −1.29% that day 2026-09-24

Daily total returns from the adjusted price series; a TLT down day is a day long yields rose. Beta = the average move of the name for a 1% move in TLT. Past sensitivity, not a forecast. An investment diary, not a recommendation.

Who it is priced against Biotechnology · US · 8 names with week and year-to-date

Peer group

Biotechnology · US

Names in the same industry from the Closelooknet universe; scored names rank on their Closelooknet score, the rest on trend state.

Compared against SYRE on the nightly bakes; the Peers tab ranks the cohort on the Closelooknet scores where it exists.

Company snapshot — Spyre Therapeutics Inc.

SYRE in five paragraphs: what it makes and sells, where it sits in the Closelooknet stack, who it is priced against, why we track it, what we watch. Research diary, not advice.

What it does
Spyre Therapeutics is a clinical-stage biotechnology company that develops antibody treatments for inflammatory bowel disease and rheumatic conditions. Its lead candidate targets the a4ß7 integrin for ulcerative colitis and Crohn's disease, alongside separate antibodies aimed at TL1A and IL-23, some combined into dual-target programmes. It was previously named Aeglea BioTherapeutics before adopting its current name in 2023, and is based in Waltham, Massachusetts.
Where it sits in the stack
Spyre sits outside the diary's AI build-out coverage; it belongs to the healthcare sector, within the biotechnology industry grouping of our wider universe, and carries no Rubin or Halo seat.
Who it is priced against
The diary holds no peer group for this name; it operates in the same clinical field as other immunology-focused developers such as AbbVie, which the market commonly names as a comparison in that therapeutic area.
Why Closelooknet tracks it
It carries a Closelooknet score, but only one module has been scored so far, so the score is still being built. It holds no index seat in the diary and has not yet been quoted in any edition.
What the diary watches
The diary watches how phase-2 results for its lead antibody candidates come through, since the shares have already moved well above their 200-day level even as the analyst price target was recently trimmed.

Spyre Therapeutics Inc. (SYRE) trades on US exchanges, classified under Healthcare.

The Closelooknet company score reads 24/100 composite (momentum 57, quality 2, valuation 6) across 7 modules — the full breakdown, chart structure and analog history load live above.

Written from the company’s public profile and Closelooknet’s own readings, 2026-09-17. Descriptive, refreshed with the registry; corrections welcome via the imprint. closelook.net is an investment research diary — market structure, index membership and scores are our own readings, not investment advice. Related: index compare · sector dispersion · scanner.

The Street on this name 3 analyst actions on the wire · latest: price target by Wedbush, 2026-08-26

The Street on this name

Analyst actions and the latest print for SYRE from the Closelooknet wires — third-party opinions on the record, not our readings.

  • Price target Wedbush — target 123 from 130 Target cut to $123 from $130 (+29.2% to spot) 2026-08-26
  • Price target BTIG — target 121 from 132 Target cut to $121 from $132 (+12.7% to spot) 2026-08-26
  • Price target Deutsche Bank — target 127 from 135 Target cut to $127 from $135 (+18.3% to spot) 2026-08-26

3 actions on the analyst wire since 2026-08-13: 3 target changes. Analyst wire → · Earnings wire →

Dividends and capital return no distribution in twelve months

Dividends and capital return

What SYRE pays out and buys back — distributions read from the price series, money terms from the filings.

  • Distributions No cash distribution recorded in the price series over the last three years
  • Share count +36.2% in FY2025 38 m USD of stock-based compensation in the year

Per-share amounts are derived from the adjusted price series in the listing currency, so dates sit within days of the ex-date; filing figures come from the fundamentals feed for the last reported fiscal year. An investment diary, not a recommendation.

FAQ · from the current data · as of 2026-10-07

Quick answers

What is Spyre Therapeutics Inc. (SYRE)?

Spyre Therapeutics Inc. trades as SYRE on the US exchange (US) and is classified under Healthcare in the Closelooknet research universe, as of the registry build of 2026-10-07.

Is SYRE in a Closelooknet index?

Not currently — Spyre Therapeutics Inc. is tracked in the Closelooknet research universe but is not a constituent of a Closelooknet functional index as of 2026-10-07.

What is Spyre Therapeutics Inc.'s Closelooknet composite score?

24 out of 100, with momentum 57, quality 2 and valuation 6 sub-scores, as of 2026-10-07. Scores are Closelooknet's own research readings, not ratings or investment advice.

Where does SYRE trade against its moving averages?

Pullback inside an uptrend stack: Trades -16% vs the 50-day and +17.5% vs the 200-day average, 27.3% below the 52-week high and +405.1% off the 52-week low. Computed from daily closes. As of 2026-10-06 — a technical state from the nightly Closelooknet bake, not advice. The Technical tab carries the full row.

How does Spyre Therapeutics Inc. compare with its peers?

Against its peer group (Biotechnology · US), Spyre Therapeutics Inc. (SYRE) sits 27.3% below its 52-week high, 16.0% below its 50-day average; BeiGene, Ltd. (ONC) is 5.8% below, Regeneron Pharmaceuticals Inc (REGN) is 15.5% below, Caris Life Sciences, Inc. Common Stock (CAI) is 18.4% below. Put any of them next to SYRE in the chart grid (2×1 or 2×2) and the page lays the companies side by side: performance, trend, valuation, margins and our money-flow reading.

How does Spyre Therapeutics Inc. trade when bond yields rise?

Over the past year Spyre Therapeutics Inc. had a beta of 0.79 to TLT, the long-dated Treasury fund — it shows only a loose link to bond moves, higher than 77% of US names. On the 10 sessions in which long bonds fell most it moved −1.36% on average, against −0.74% for the S&P 500. The "How it trades on rate days" block on this page carries the lines.

What does Spyre Therapeutics Inc. do?

Spyre Therapeutics is a clinical-stage biotechnology company that develops antibody treatments for inflammatory bowel disease and rheumatic conditions. Its lead candidate targets the a4ß7 integrin for ulcerative colitis and Crohn's disease, alongside separate antibodies aimed at TL1A and IL-23, some combined into dual-target programmes. It was previously named Aeglea BioTherapeutics before adopting its current name in 2023, and is based in Waltham, Massachusetts. The diary holds no peer group for this name; it operates in the same clinical field as other immunology-focused developers such as AbbVie, which the market commonly names as a comparison in that therapeutic area.

Where does Spyre Therapeutics Inc. sit in the AI build-out?

Spyre sits outside the diary's AI build-out coverage; it belongs to the healthcare sector, within the biotechnology industry grouping of our wider universe, and carries no Rubin or Halo seat. It carries a Closelooknet score, but only one module has been scored so far, so the score is still being built. It holds no index seat in the diary and has not yet been quoted in any edition.

Does Spyre Therapeutics Inc. pay a dividend?

No cash distribution shows in Spyre Therapeutics Inc.’s price series over the last three years. The share count rose 36.2% over the fiscal year. The "Dividends and capital return" block on this page carries the lines.

What has Wall Street done on Spyre Therapeutics Inc. recently?

The most recent analyst action on Spyre Therapeutics Inc. on the Closelooknet wire is a price target by Wedbush on 2026-08-26 (target 123 from 130). 3 actions on the analyst wire since 2026-08-13: 3 target changes. Analyst actions are third-party opinions recorded by the wire, not Closelooknet readings. The “The Street on this name” block on this page lists the moves; the full feeds are the analyst wire and the earnings wire.

What does this page show?

A live price chart with SMA overlays and drawing tools for SYRE, performance metrics, index-membership context and the Closelooknet structure read — an investment research diary view, not investment advice.

Related in the Closelooknet universe

then Biotechnology. Scored names rank on their Closelooknet score; names without one rank on trend state — above or below their 50- and 200-day averages — never on a score they do not carry.